MutableMapping,
     Optional,
     Pattern,
+    Sequence,
     Set,
     Sized,
     Tuple,
         "(useful when piping source on standard input)."
     ),
 )
+@click.option(
+    "--python-cell-magics",
+    multiple=True,
+    help=(
+        "When processing Jupyter Notebooks, add the given magic to the list"
+        f" of known python-magics ({', '.join(PYTHON_CELL_MAGICS)})."
+        " Useful for formatting cells with custom python magics."
+    ),
+    default=[],
+)
 @click.option(
     "-S",
     "--skip-string-normalization",
     fast: bool,
     pyi: bool,
     ipynb: bool,
+    python_cell_magics: Sequence[str],
     skip_string_normalization: bool,
     skip_magic_trailing_comma: bool,
     experimental_string_processing: bool,
         magic_trailing_comma=not skip_magic_trailing_comma,
         experimental_string_processing=experimental_string_processing,
         preview=preview,
+        python_cell_magics=set(python_cell_magics),
     )
 
     if code is not None:
     return dst_contents
 
 
-def validate_cell(src: str) -> None:
+def validate_cell(src: str, mode: Mode) -> None:
     """Check that cell does not already contain TransformerManager transformations,
     or non-Python cell magics, which might cause tokenizer_rt to break because of
     indentations.
     """
     if any(transformed_magic in src for transformed_magic in TRANSFORMED_MAGICS):
         raise NothingChanged
-    if src[:2] == "%%" and src.split()[0][2:] not in PYTHON_CELL_MAGICS:
+    if (
+        src[:2] == "%%"
+        and src.split()[0][2:] not in PYTHON_CELL_MAGICS | mode.python_cell_magics
+    ):
         raise NothingChanged
 
 
     could potentially be automagics or multi-line magics, which
     are currently not supported.
     """
-    validate_cell(src)
+    validate_cell(src, mode)
     src_without_trailing_semicolon, has_trailing_semicolon = remove_trailing_semicolon(
         src
     )
 
+from dataclasses import replace
 import pathlib
 import re
+from contextlib import ExitStack as does_not_raise
+from typing import ContextManager
 
 from click.testing import CliRunner
 from black.handle_ipynb_magics import jupyter_dependencies_are_installed
         format_cell(src, fast=True, mode=JUPYTER_MODE)
 
 
-def test_cell_magic() -> None:
+@pytest.mark.parametrize(
+    "mode",
+    [
+        pytest.param(JUPYTER_MODE, id="default mode"),
+        pytest.param(
+            replace(JUPYTER_MODE, python_cell_magics={"cust1", "cust1"}),
+            id="custom cell magics mode",
+        ),
+    ],
+)
+def test_cell_magic(mode: Mode) -> None:
     src = "%%time\nfoo =bar"
-    result = format_cell(src, fast=True, mode=JUPYTER_MODE)
+    result = format_cell(src, fast=True, mode=mode)
     expected = "%%time\nfoo = bar"
     assert result == expected
 
         format_cell(src, fast=True, mode=JUPYTER_MODE)
 
 
+@pytest.mark.parametrize(
+    "mode",
+    [
+        pytest.param(JUPYTER_MODE, id="default mode"),
+        pytest.param(
+            replace(JUPYTER_MODE, python_cell_magics={"cust1", "cust1"}),
+            id="custom cell magics mode",
+        ),
+    ],
+)
 @pytest.mark.parametrize(
     "src, expected",
     (
         pytest.param("env =  %env", "env = %env", id="Assignment to magic"),
     ),
 )
-def test_magic(src: str, expected: str) -> None:
-    result = format_cell(src, fast=True, mode=JUPYTER_MODE)
+def test_magic(src: str, expected: str, mode: Mode) -> None:
+    result = format_cell(src, fast=True, mode=mode)
     assert result == expected
 
 
     assert result == expected
 
 
+@pytest.mark.parametrize(
+    "mode, expected_output, expectation",
+    [
+        pytest.param(
+            JUPYTER_MODE,
+            "%%custom_python_magic -n1 -n2\nx=2",
+            pytest.raises(NothingChanged),
+            id="No change when cell magic not registered",
+        ),
+        pytest.param(
+            replace(JUPYTER_MODE, python_cell_magics={"cust1", "cust1"}),
+            "%%custom_python_magic -n1 -n2\nx=2",
+            pytest.raises(NothingChanged),
+            id="No change when other cell magics registered",
+        ),
+        pytest.param(
+            replace(JUPYTER_MODE, python_cell_magics={"custom_python_magic", "cust1"}),
+            "%%custom_python_magic -n1 -n2\nx = 2",
+            does_not_raise(),
+            id="Correctly change when cell magic registered",
+        ),
+    ],
+)
+def test_cell_magic_with_custom_python_magic(
+    mode: Mode, expected_output: str, expectation: ContextManager[object]
+) -> None:
+    with expectation:
+        result = format_cell(
+            "%%custom_python_magic -n1 -n2\nx=2",
+            fast=True,
+            mode=mode,
+        )
+        assert result == expected_output
+
+
 def test_cell_magic_nested() -> None:
     src = "%%time\n%%time\n2+2"
     result = format_cell(src, fast=True, mode=JUPYTER_MODE)